Each 100 gm contains : Acyclovir 5 mg.
Pharmacology: Pharmacodynamics: ZEVIN (Acyclovir) is a synthetic acyclic nucleoside analogue with in vitro inhibitory activity against Herpes simplex type 1 and 2 (HSV-1 and HSV-2), varicella-zoster, Epstein-Barr and cytomegalovirus. In cell cultures, the inhibitory activity of acyclovir for Herpes simplex virus is highly selective.
Acyclovir is poorly absorbed following oral administration, with peak plasma levels occurring in 1.7 hours. Acyclovir is metabolized in liver.
Plasma protein-binding is low. The half-life is 3.3 hours. Approximately 14% of total dose excreted unchanged in urine.
Absorption of acyclovir is usually slight following topical application to intact skin. In disease skin (Herpes zoster), moderate plasma concentrations up to 0.28 mcg/ml have been reported in patients with normal renal function.
Approximately 9% of the total daily dose may be excreted in the urine.
For in treatment of Herpes simplex virus infection of the skin including initial and recurrent genital herpes and herpes labialis.
Apply ZEVIN CREAM five times daily at approximately four hourly intervals. ZEVIN should be applied to lesions as early as possible after the start of an infection. Treatment should be continued for 5 days and for recurrent episodes this should preferably be during the prodromal period or when the lesions first appear.
Overdosage of acyclovir may cause renal dysfunction and eventually renal failure and anuria according to the precipitation of acyclovir crystals in the renal tubules. If acute renal failure and anuria occur, dosage of the drug should be adjusted and hemodialysis considered until the renal function is restored.
ZEVIN is contraindicated in patients known to be hypersensitive to acyclovir or propylene glycol.
Should avoid sexual contact while visible lesions are present because of the risk of infecting intimate partners.
Should be cautions not to exceed the prescribed dosage.
Do not apply to the mucous membrane eg. in the mouth, eyes or vagina as it may be irritant. Particular care should be taken to avoid accidental introduction into the eyes.
Use in Pregnancy: Limit data are available on the use of acyclovir in pregnancy.
Caution should therefore be exercised by balancing the potential benefits of treatment against any possible hazard.
Use in Lactation: Limit data indicate that acyclovir is distributed into milk following systemic administration. Caution therefore advised if ZEVIN is to be administered to a nursing woman.
Use in pregnancy: Limit data are available on the use of acyclovir in pregnancy.
Caution should therefore be exercised by balancing the potential benefits of treatment against any possible hazard.
Use in lactation: Limit data indicate that acyclovir is distributed into milk following systemic administration. Caution therefore advised if ZEVIN is to be administered to a nursing woman.
Transient burning or stinging following application of acyclovir cream may occur. Erythema or mild drying and flaking of the skin have been reported in a small proportion of patients.
Concomitant administration of probenecid and acyclovir has reportedly increased the mean plasma half life and area under the plasma concentration time curve (AUC) and decreased urinary excretion and renal clearance of acyclovir. This interaction may result from the competitive inhibition of the renal secretion of acyclovir by probenecid.
Store below 30°C. The shelf life period is 3 years.
D06BB03 - aciclovir ; Belongs to the class of topical antivirals used in the treatment of dermatological diseases.
Zevin cream 5%
10 g x 1's
Sign Out
